Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4715974..4716581 Replicon chromosome
Accession NZ_CP058191
Organism Enterobacter hormaechei strain RHBSTW-00012

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag HV033_RS22715 Protein ID WP_071788668.1
Coordinates 4716396..4716581 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HV033_RS22710 Protein ID WP_063147030.1
Coordinates 4715974..4716381 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV033_RS22680 4711815..4712468 + 654 WP_063147029.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
HV033_RS22685 4712471..4713331 + 861 WP_023298863.1 L-ribulose-5-phosphate 3-epimerase -
HV033_RS22690 4713325..4714020 + 696 WP_038416909.1 L-ribulose-5-phosphate 4-epimerase -
HV033_RS22695 4714021..4714308 - 288 Protein_4435 helix-turn-helix domain-containing protein -
HV033_RS22700 4714303..4714692 + 390 Protein_4436 glycoside hydrolase family 127 protein -
HV033_RS22705 4714894..4715970 + 1077 WP_047354172.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
HV033_RS22710 4715974..4716381 - 408 WP_063147030.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HV033_RS22715 4716396..4716581 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
HV033_RS22720 4716825..4718363 - 1539 WP_023307168.1 aldehyde dehydrogenase AldB -
HV033_RS22725 4718530..4719414 + 885 WP_023298868.1 ROK family protein -
HV033_RS22730 4719418..4721256 - 1839 WP_063147031.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T166090 WP_071788668.1 NZ_CP058191:c4716581-4716396 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T166090 NZ_CP074032:c65402-65253 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15146.93 Da        Isoelectric Point: 4.4217

>AT166090 WP_063147030.1 NZ_CP058191:c4716381-4715974 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDAREALTAHFEALFEMDEALPLPGNVEVHLENHPDDFSGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Download         Length: 408 bp

>AT166090 NZ_CP074032:65446-65507 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure

References