Detailed information of TA system TA166089

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3904048..3904705
• Replicon: chromosome
• Accession: NZ_CP058191
• Organism: Enterobacter hormaechei strain RHBSTW-00012

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: HV033_RS18645
• Protein ID: WP_063146504.1
• Coordinates: 3904048..3904458 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: HV033_RS18650
• Protein ID: WP_003863437.1
• Coordinates: 3904439..3904705 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV033_RS18625	3900046..3901779	-	1734	WP_063146503.1	single-stranded-DNA-specific exonuclease RecJ	-
HV033_RS18630	3901785..3902498	-	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
HV033_RS18635	3902527..3903423	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
HV033_RS18640	3903525..3904046	+	522	WP_015571793.1	flavodoxin FldB	-
HV033_RS18645	3904048..3904458	-	411	WP_063146504.1	protein YgfX	Toxin
HV033_RS18650	3904439..3904705	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
HV033_RS18655	3905000..3905980	+	981	WP_063146505.1	tRNA-modifying protein YgfZ	-
HV033_RS18660	3906502..3907161	-	660	WP_022649307.1	hemolysin III family protein	-
HV033_RS18665	3907428..3908159	+	732	WP_063146842.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16312.19 Da
• Isoelectric Point: 11.4775

>T166089 WP_063146504.1 NZ_CP058191:c3904458-3904048 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQQLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T166089 NZ_CP074032:21331-21747 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT166089 WP_003863437.1 NZ_CP058191:c3904705-3904439 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT166089 NZ_CP074032:21104-21334 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5