Detailed information of TA system TA166080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2434367..2435106
• Replicon: chromosome
• Accession: NZ_CP058191
• Organism: Enterobacter hormaechei strain RHBSTW-00012

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: HV033_RS11615
• Protein ID: WP_063139083.1
• Coordinates: 2434367..2434852 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A837FCR9
• Locus tag: HV033_RS11620
• Protein ID: WP_003857131.1
• Coordinates: 2434840..2435106 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV033_RS11600	2430586..2431485	+	900	WP_063145897.1	LysR family transcriptional regulator	-
HV033_RS11605	2431578..2432477	+	900	WP_063145896.1	LysR family transcriptional regulator	-
HV033_RS11610	2432708..2434150	-	1443	WP_080472609.1	ISNCY family transposase	-
HV033_RS11615	2434367..2434852	-	486	WP_063139083.1	GNAT family N-acetyltransferase	Toxin
HV033_RS11620	2434840..2435106	-	267	WP_003857131.1	DUF1778 domain-containing protein	Antitoxin
HV033_RS11625	2435170..2436099	-	930	WP_063145894.1	LysR family transcriptional regulator	-
HV033_RS11630	2436229..2437617	+	1389	WP_063145893.1	MFS transporter	-
HV033_RS11635	2437596..2438153	-	558	WP_045622668.1	OmpH family outer membrane protein	-
HV033_RS11640	2438274..2439410	-	1137	WP_063145892.1	type 1 fimbrial protein	-
HV033_RS11645	2439434..2439958	-	525	WP_087878309.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2432708..2434108	1400

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (58-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17544.22 Da
• Isoelectric Point: 9.6275

>T166080 WP_063139083.1 NZ_CP058191:c2434852-2434367 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T166080 NZ_CP058191:c2434852-2434367 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCGCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCG
CAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10090.50 Da
• Isoelectric Point: 4.3837

>AT166080 WP_003857131.1 NZ_CP058191:c2435106-2434840 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT166080 NZ_CP058191:c2435106-2434840 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FCR9