Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1225596..1226217 Replicon chromosome
Accession NZ_CP058191
Organism Enterobacter hormaechei strain RHBSTW-00012

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV033_RS05855 Protein ID WP_015571250.1
Coordinates 1225596..1225814 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV033_RS05860 Protein ID WP_006809850.1
Coordinates 1225843..1226217 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV033_RS05825 1221608..1221868 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV033_RS05830 1221871..1222011 + 141 WP_063146587.1 type B 50S ribosomal protein L36 -
HV033_RS05835 1222008..1222718 - 711 WP_063146586.1 GNAT family N-acetyltransferase -
HV033_RS05840 1222821..1224281 + 1461 WP_063146585.1 PLP-dependent aminotransferase family protein -
HV033_RS05845 1224253..1224720 - 468 WP_022647269.1 hypothetical protein -
HV033_RS05850 1224837..1225388 - 552 WP_063146584.1 maltose O-acetyltransferase -
HV033_RS05855 1225596..1225814 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV033_RS05860 1225843..1226217 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV033_RS05865 1226727..1229873 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HV033_RS05870 1229896..1231089 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T166079 WP_015571250.1 NZ_CP058191:c1225814-1225596 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T166079 NZ_CP074031:c2828215-2828113 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT166079 WP_006809850.1 NZ_CP058191:c1226217-1225843 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT166079 NZ_CP074031:2828075-2828346 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References