Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 864069..864588 Replicon chromosome
Accession NZ_CP058191
Organism Enterobacter hormaechei strain RHBSTW-00012

Toxin (Protein)


Gene name parE Uniprot ID A0A837F4A9
Locus tag HV033_RS04185 Protein ID WP_000277490.1
Coordinates 864304..864588 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A6P1V8C3
Locus tag HV033_RS04180 Protein ID WP_000124732.1
Coordinates 864069..864311 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV033_RS04145 859158..859463 - 306 WP_000534920.1 hypothetical protein -
HV033_RS04150 859517..859768 - 252 WP_000181753.1 hypothetical protein -
HV033_RS04155 859847..861118 - 1272 WP_181241345.1 Y-family DNA polymerase -
HV033_RS04160 861118..861543 - 426 WP_001776124.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
HV033_RS04165 861605..861757 - 153 Protein_807 transposase -
HV033_RS04170 861815..862519 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
HV033_RS04175 862567..863496 + 930 WP_162534819.1 replication initiator protein RepA -
HV033_RS04180 864069..864311 + 243 WP_000124732.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
HV033_RS04185 864304..864588 + 285 WP_000277490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV033_RS04190 864726..864818 - 93 Protein_812 DNA partition complex ParG -
HV033_RS04195 865235..865939 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
HV033_RS04200 865930..866061 + 132 WP_099743461.1 helix-turn-helix domain-containing protein -
HV033_RS04205 867473..868948 - 1476 WP_020324153.1 SEC-C domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ugd 836186..871338 35152
- inside IScluster/Tn - - 861815..874256 12441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-88)

Antitoxin

Antitoxin ParD

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11005.52 Da        Isoelectric Point: 6.2103

>T166078 WP_000277490.1 NZ_CP058191:864304-864588 [Enterobacter hormaechei]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL

Download         Length: 285 bp

>T166078 NZ_CP074031:c2466589-2466311 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCAGATATCGATATGCCCGGTTACCGATTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGGATAACGTTCGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8875.01 Da        Isoelectric Point: 7.0130

>AT166078 WP_000124732.1 NZ_CP058191:864069-864311 [Enterobacter hormaechei]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV

Download         Length: 243 bp

>AT166078 NZ_CP074031:c2466311-2466027 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGCCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837F4A9

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V8C3

References