Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 63036..63679 | Replicon | plasmid pRHBSTW-00016_2 |
Accession | NZ_CP058188 | ||
Organism | Enterobacter hormaechei strain RHBSTW-00016 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | A0A6C0NE46 |
Locus tag | HV036_RS23445 | Protein ID | WP_008322233.1 |
Coordinates | 63263..63679 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q84A07 |
Locus tag | HV036_RS23440 | Protein ID | WP_001261276.1 |
Coordinates | 63036..63266 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV036_RS23415 | 58864..59124 | - | 261 | WP_040219223.1 | type II toxin-antitoxin system ParD family antitoxin | - |
HV036_RS23420 | 59497..59727 | + | 231 | WP_008322219.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
HV036_RS23425 | 59724..60140 | + | 417 | WP_071687807.1 | type II toxin-antitoxin system VapC family toxin | - |
HV036_RS23430 | 60214..61776 | + | 1563 | WP_008322224.1 | AAA family ATPase | - |
HV036_RS23435 | 61761..62783 | + | 1023 | WP_008322227.1 | helicase UvrD | - |
HV036_RS23440 | 63036..63266 | + | 231 | WP_001261276.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
HV036_RS23445 | 63263..63679 | + | 417 | WP_008322233.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
HV036_RS23450 | 63873..64042 | + | 170 | Protein_81 | DUF596 domain-containing protein | - |
HV036_RS23455 | 64225..65145 | - | 921 | WP_071687809.1 | carbohydrate kinase | - |
HV036_RS23460 | 65142..66512 | - | 1371 | WP_008322237.1 | hypothetical protein | - |
HV036_RS23465 | 66590..67609 | - | 1020 | WP_004113181.1 | ribose ABC transporter permease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | sul1 / qacE / aadA2 | mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA | 1..169857 | 169857 | |
- | flank | IS/Tn | - | - | 57820..58788 | 968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15054.58 Da Isoelectric Point: 9.2957
>T166075 WP_008322233.1 NZ_CP058188:63263-63679 [Enterobacter hormaechei]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAASAVLVTNNVREFARVPGLMLEDWVK
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAASAVLVTNNVREFARVPGLMLEDWVK
Download Length: 417 bp
>T166075 NZ_CP074031:c2184717-2184610 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8721.74 Da Isoelectric Point: 4.3533
>AT166075 WP_001261276.1 NZ_CP058188:63036-63266 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT166075 NZ_CP074031:2184765-2184831 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6C0NE46 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A387K023 |