Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 63036..63679 Replicon plasmid pRHBSTW-00016_2
Accession NZ_CP058188
Organism Enterobacter hormaechei strain RHBSTW-00016

Toxin (Protein)


Gene name vagD Uniprot ID A0A6C0NE46
Locus tag HV036_RS23445 Protein ID WP_008322233.1
Coordinates 63263..63679 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag HV036_RS23440 Protein ID WP_001261276.1
Coordinates 63036..63266 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV036_RS23415 58864..59124 - 261 WP_040219223.1 type II toxin-antitoxin system ParD family antitoxin -
HV036_RS23420 59497..59727 + 231 WP_008322219.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HV036_RS23425 59724..60140 + 417 WP_071687807.1 type II toxin-antitoxin system VapC family toxin -
HV036_RS23430 60214..61776 + 1563 WP_008322224.1 AAA family ATPase -
HV036_RS23435 61761..62783 + 1023 WP_008322227.1 helicase UvrD -
HV036_RS23440 63036..63266 + 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV036_RS23445 63263..63679 + 417 WP_008322233.1 type II toxin-antitoxin system VapC family toxin Toxin
HV036_RS23450 63873..64042 + 170 Protein_81 DUF596 domain-containing protein -
HV036_RS23455 64225..65145 - 921 WP_071687809.1 carbohydrate kinase -
HV036_RS23460 65142..66512 - 1371 WP_008322237.1 hypothetical protein -
HV036_RS23465 66590..67609 - 1020 WP_004113181.1 ribose ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aadA2 mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA 1..169857 169857
- flank IS/Tn - - 57820..58788 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15054.58 Da        Isoelectric Point: 9.2957

>T166075 WP_008322233.1 NZ_CP058188:63263-63679 [Enterobacter hormaechei]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAASAVLVTNNVREFARVPGLMLEDWVK

Download         Length: 417 bp

>T166075 NZ_CP074031:c2184717-2184610 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT166075 WP_001261276.1 NZ_CP058188:63036-63266 [Enterobacter hormaechei]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT166075 NZ_CP074031:2184765-2184831 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C0NE46

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References