Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4710566..4711182 Replicon chromosome
Accession NZ_CP058187
Organism Enterobacter hormaechei strain RHBSTW-00016

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV036_RS22650 Protein ID WP_080346796.1
Coordinates 4710566..4710937 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV036_RS22655 Protein ID WP_023298920.1
Coordinates 4710940..4711182 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV036_RS22635 4708066..4708968 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV036_RS22640 4708965..4709600 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV036_RS22645 4709597..4710526 + 930 WP_023305104.1 formate dehydrogenase accessory protein FdhE -
HV036_RS22650 4710566..4710937 - 372 WP_080346796.1 type II toxin-antitoxin system VapC family toxin Toxin
HV036_RS22655 4710940..4711182 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV036_RS22660 4711382..4712302 + 921 WP_023305106.1 alpha/beta hydrolase -
HV036_RS22665 4712311..4713252 - 942 WP_023305107.1 fatty acid biosynthesis protein FabY -
HV036_RS22670 4713297..4713734 - 438 WP_023305108.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV036_RS22675 4713731..4714612 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV036_RS22680 4714606..4715205 - 600 WP_023305109.1 glucose-1-phosphatase -
HV036_RS22685 4715324..4716124 - 801 WP_023305110.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13668.73 Da        Isoelectric Point: 6.2151

>T166073 WP_080346796.1 NZ_CP058187:c4710937-4710566 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMEAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T166073 NZ_CP074031:1139607-1139942 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTCAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTTGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT166073 WP_023298920.1 NZ_CP058187:c4711182-4710940 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT166073 NZ_CP074031:1139359-1139607 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCTCCTGCAGTGCGGATCCCAGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGGCCTGGTGGATGGCAAATTAATTATTGAGCCAGTACGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAGCGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References