Detailed information of TA system TA166071

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3566873..3567540
• Replicon: chromosome
• Accession: NZ_CP058187
• Organism: Enterobacter hormaechei strain RHBSTW-00016

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: HV036_RS17110
• Protein ID: WP_057064441.1
• Coordinates: 3567211..3567540 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV036_RS17105
• Protein ID: WP_007870247.1
• Coordinates: 3566873..3567190 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV036_RS17085	3562605..3564800	+	2196	WP_000093087.1	DEAD/DEAH box helicase	-
HV036_RS17090	3565654..3566133	+	480	WP_108168719.1	antirestriction protein	-
HV036_RS17095	3566149..3566625	+	477	WP_057064440.1	RadC family protein	-
HV036_RS17100	3566634..3566855	+	222	WP_001548165.1	DUF987 domain-containing protein	-
HV036_RS17105	3566873..3567190	+	318	WP_007870247.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV036_RS17110	3567211..3567540	+	330	WP_057064441.1	TA system toxin CbtA family protein	Toxin
HV036_RS17115	3568225..3569151	-	927	WP_023306741.1	helix-turn-helix domain-containing protein	-
HV036_RS17120	3569301..3571025	-	1725	WP_023306742.1	flagellin	-
HV036_RS17125	3571795..3572217	-	423	WP_032671399.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3565654..3599829	34175

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12424.59 Da
• Isoelectric Point: 10.1006

>T166071 WP_057064441.1 NZ_CP058187:3567211-3567540 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFWDQTVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKAKVK

Nucleotide

• Length: 330 bp

>T166071 NZ_CP074031:c905007-904633 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11839.44 Da
• Isoelectric Point: 6.9459

>AT166071 WP_007870247.1 NZ_CP058187:3566873-3567190 [Enterobacter hormaechei]
MNNTTWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT166071 NZ_CP074031:c905465-905097 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA