Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1129815..1130436 Replicon chromosome
Accession NZ_CP058187
Organism Enterobacter hormaechei strain RHBSTW-00016

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV036_RS05320 Protein ID WP_015571250.1
Coordinates 1129815..1130033 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV036_RS05325 Protein ID WP_006809850.1
Coordinates 1130062..1130436 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV036_RS05290 1125827..1126087 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV036_RS05295 1126090..1126230 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV036_RS05300 1126227..1126937 - 711 WP_023305593.1 GNAT family N-acetyltransferase -
HV036_RS05305 1127040..1128500 + 1461 WP_023305594.1 PLP-dependent aminotransferase family protein -
HV036_RS05310 1128472..1128939 - 468 WP_023305595.1 hypothetical protein -
HV036_RS05315 1129056..1129607 - 552 WP_108168561.1 maltose O-acetyltransferase -
HV036_RS05320 1129815..1130033 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV036_RS05325 1130062..1130436 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV036_RS05330 1130946..1134092 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HV036_RS05335 1134115..1135308 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T166061 WP_015571250.1 NZ_CP058187:c1130033-1129815 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T166061 NZ_CP074028:4040438-4040773 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT166061 WP_006809850.1 NZ_CP058187:c1130436-1130062 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT166061 NZ_CP074028:4040190-4040438 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References