Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5907039..5907649 Replicon chromosome
Accession NZ_CP058180
Organism Klebsiella grimontii strain RHBSTW-00039

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag HV042_RS28270 Protein ID WP_049086919.1
Coordinates 5907039..5907413 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV042_RS28275 Protein ID WP_077253475.1
Coordinates 5907410..5907649 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV042_RS28255 5904194..5905096 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
HV042_RS28260 5905093..5905728 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
HV042_RS28265 5906072..5907001 + 930 WP_181334685.1 formate dehydrogenase accessory protein FdhE -
HV042_RS28270 5907039..5907413 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
HV042_RS28275 5907410..5907649 - 240 WP_077253475.1 ribbon-helix-helix domain-containing protein Antitoxin
HV042_RS28280 5907855..5908772 + 918 WP_024360706.1 alpha/beta hydrolase -
HV042_RS28285 5908790..5909731 - 942 WP_181334686.1 fatty acid biosynthesis protein FabY -
HV042_RS28290 5909776..5910213 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV042_RS28295 5910210..5911070 - 861 WP_004127107.1 virulence factor BrkB family protein -
HV042_RS28300 5911064..5911663 - 600 WP_004132872.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T166058 WP_049086919.1 NZ_CP058180:c5907413-5907039 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T166058 NZ_CP074028:3328787-3329314 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT166058 WP_077253475.1 NZ_CP058180:c5907649-5907410 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp

>AT166058 NZ_CP074028:3328514-3328780 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References