Detailed information of TA system TA166057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4771729..4772548
• Replicon: chromosome
• Accession: NZ_CP058180
• Organism: Klebsiella grimontii strain RHBSTW-00039

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A9E1D5M6
• Locus tag: HV042_RS22870
• Protein ID: WP_004132607.1
• Coordinates: 4772291..4772548 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: HV042_RS22865
• Protein ID: WP_004132606.1
• Coordinates: 4771729..4772280 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV042_RS22850	4767119..4768516	+	1398	WP_004132593.1	MFS transporter	-
HV042_RS22855	4768640..4769980	+	1341	WP_049085654.1	carbohydrate porin	-
HV042_RS22860	4770083..4771711	-	1629	WP_049085653.1	SAM-dependent methyltransferase	-
HV042_RS22865	4771729..4772280	-	552	WP_004132606.1	N-acetyltransferase	Antitoxin
HV042_RS22870	4772291..4772548	-	258	WP_004132607.1	YjhX family toxin	Toxin
HV042_RS22875	4773132..4774316	+	1185	WP_049085652.1	mannonate dehydratase	-
HV042_RS22880	4774393..4775868	+	1476	WP_024359122.1	fructuronate reductase	-
HV042_RS22885	4776005..4776781	+	777	WP_024359123.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.04 Da
• Isoelectric Point: 11.1381

>T166057 WP_004132607.1 NZ_CP058180:c4772548-4772291 [Klebsiella grimontii]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T166057 NZ_CP074028:3307221-3307451 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT166057 WP_004132606.1 NZ_CP058180:c4772280-4771729 [Klebsiella grimontii]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT166057 NZ_CP074028:3307448-3307807 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA