166056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4552392..4553011 Replicon chromosome
Accession NZ_CP058180
Organism Klebsiella grimontii strain RHBSTW-00039

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag HV042_RS21835 Protein ID WP_004099646.1
Coordinates 4552793..4553011 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag HV042_RS21830 Protein ID WP_004129911.1
Coordinates 4552392..4552766 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV042_RS21820 4547561..4548754 + 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV042_RS21825 4548777..4551923 + 3147 WP_004848339.1 multidrug efflux RND transporter permease subunit -
HV042_RS21830 4552392..4552766 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
HV042_RS21835 4552793..4553011 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
HV042_RS21840 4553173..4553739 + 567 WP_049085237.1 maltose O-acetyltransferase -
HV042_RS21845 4553866..4554336 + 471 WP_004136048.1 YlaC family protein -
HV042_RS21850 4554311..4555765 - 1455 WP_049085239.1 PLP-dependent aminotransferase family protein -
HV042_RS21855 4555866..4556564 + 699 WP_004136044.1 GNAT family N-acetyltransferase -
HV042_RS21860 4556561..4556701 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV042_RS21865 4556701..4556964 - 264 WP_004129897.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T166056 WP_004099646.1 NZ_CP058180:4552793-4553011 [Klebsiella grimontii]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T166056 NZ_CP074028:c2835409-2835098 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT166056 WP_004129911.1 NZ_CP058180:4552392-4552766 [Klebsiella grimontii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT166056 NZ_CP074028:c2835097-2834807 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References