Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3856254..3856911 Replicon chromosome
Accession NZ_CP058175
Organism Enterobacter hormaechei strain RHBSTW-00040

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag HV043_RS18760 Protein ID WP_022649305.1
Coordinates 3856254..3856664 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV043_RS18765 Protein ID WP_003863437.1
Coordinates 3856645..3856911 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV043_RS18740 3852252..3853985 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
HV043_RS18745 3853991..3854704 - 714 WP_023306885.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV043_RS18750 3854733..3855629 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
HV043_RS18755 3855731..3856252 + 522 WP_023306886.1 flavodoxin FldB -
HV043_RS18760 3856254..3856664 - 411 WP_022649305.1 protein YgfX Toxin
HV043_RS18765 3856645..3856911 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV043_RS18770 3857206..3858186 + 981 WP_023298542.1 tRNA-modifying protein YgfZ -
HV043_RS18775 3858710..3859369 - 660 WP_022649307.1 hemolysin III family protein -
HV043_RS18780 3859636..3860367 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T166042 WP_022649305.1 NZ_CP058175:c3856664-3856254 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T166042 NZ_CP074028:95498-95752 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT166042 WP_003863437.1 NZ_CP058175:c3856911-3856645 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT166042 NZ_CP074028:95250-95501 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References