Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2411438..2412177 Replicon chromosome
Accession NZ_CP058175
Organism Enterobacter hormaechei strain RHBSTW-00040

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV043_RS11950 Protein ID WP_032624244.1
Coordinates 2411438..2411923 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag HV043_RS11955 Protein ID WP_003857131.1
Coordinates 2411911..2412177 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV043_RS11920 2406999..2407583 - 585 WP_023306207.1 NUDIX hydrolase -
HV043_RS11925 2407670..2408428 + 759 WP_063160026.1 DeoR/GlpR family DNA-binding transcription regulator -
HV043_RS11930 2408533..2409825 + 1293 Protein_2326 glycoside hydrolase -
HV043_RS11935 2410125..2410406 + 282 Protein_2327 DUF4225 domain-containing protein -
HV043_RS11940 2410381..2410710 - 330 WP_023306210.1 hypothetical protein -
HV043_RS11945 2410843..2411412 + 570 WP_023306211.1 hypothetical protein -
HV043_RS11950 2411438..2411923 - 486 WP_032624244.1 GNAT family N-acetyltransferase Toxin
HV043_RS11955 2411911..2412177 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
HV043_RS11960 2412241..2413170 - 930 WP_023306213.1 LysR family transcriptional regulator -
HV043_RS11965 2413300..2414688 + 1389 WP_023306214.1 MFS transporter -
HV043_RS11970 2414667..2415224 - 558 WP_023300131.1 OmpH family outer membrane protein -
HV043_RS11975 2415345..2416481 - 1137 WP_032676232.1 type 1 fimbrial protein -
HV043_RS11980 2416505..2417029 - 525 WP_087878309.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17531.27 Da        Isoelectric Point: 10.1788

>T166033 WP_032624244.1 NZ_CP058175:c2411923-2411438 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEKAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T166033 NZ_CP074024:2695745-2695852 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT166033 WP_003857131.1 NZ_CP058175:c2412177-2411911 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT166033 NZ_CP074024:c2695698-2695632 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References