Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4058268..4058925 Replicon chromosome
Accession NZ_CP058172
Organism Enterobacter hormaechei strain RHBSTW-00056

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag HV047_RS20010 Protein ID WP_022649305.1
Coordinates 4058268..4058678 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV047_RS20015 Protein ID WP_003863437.1
Coordinates 4058659..4058925 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV047_RS19990 4054266..4055999 - 1734 WP_048965620.1 single-stranded-DNA-specific exonuclease RecJ -
HV047_RS19995 4056005..4056718 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV047_RS20000 4056747..4057643 - 897 WP_048965619.1 site-specific tyrosine recombinase XerD -
HV047_RS20005 4057745..4058266 + 522 WP_015571793.1 flavodoxin FldB -
HV047_RS20010 4058268..4058678 - 411 WP_022649305.1 protein YgfX Toxin
HV047_RS20015 4058659..4058925 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV047_RS20020 4059219..4060199 + 981 WP_045622914.1 tRNA-modifying protein YgfZ -
HV047_RS20025 4060721..4061380 - 660 WP_022649307.1 hemolysin III family protein -
HV047_RS20030 4061647..4062378 + 732 WP_155025208.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T166028 WP_022649305.1 NZ_CP058172:c4058678-4058268 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T166028 NZ_CP074024:1841769-1842020 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT166028 WP_003863437.1 NZ_CP058172:c4058925-4058659 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT166028 NZ_CP074024:1842017-1842271 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References