Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 57636..58161 | Replicon | plasmid pRHBSTW-00059_2 |
| Accession | NZ_CP058168 | ||
| Organism | Enterobacter hormaechei strain RHBSTW-00059 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A7H9K2T5 |
| Locus tag | HV048_RS22890 | Protein ID | WP_045616569.1 |
| Coordinates | 57856..58161 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A8H9ZZC6 |
| Locus tag | HV048_RS22885 | Protein ID | WP_016240352.1 |
| Coordinates | 57636..57854 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV048_RS22845 | 53006..53449 | - | 444 | WP_032413443.1 | DUF2384 domain-containing protein | - |
| HV048_RS22850 | 53550..53779 | - | 230 | Protein_54 | DUF4113 domain-containing protein | - |
| HV048_RS22855 | 53820..54137 | + | 318 | Protein_55 | transposase | - |
| HV048_RS22860 | 54351..54770 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | - |
| HV048_RS22865 | 54767..55078 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | - |
| HV048_RS22870 | 55283..56343 | - | 1061 | Protein_58 | IS3 family transposase | - |
| HV048_RS22875 | 56393..56809 | - | 417 | WP_057072957.1 | type II toxin-antitoxin system VapC family toxin | - |
| HV048_RS22880 | 56806..57036 | - | 231 | WP_057072956.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| HV048_RS22885 | 57636..57854 | + | 219 | WP_016240352.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| HV048_RS22890 | 57856..58161 | + | 306 | WP_045616569.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| HV048_RS22895 | 58331..59347 | + | 1017 | WP_063216424.1 | hypothetical protein | - |
| HV048_RS22900 | 59545..60339 | + | 795 | WP_016240356.1 | site-specific integrase | - |
| HV048_RS22905 | 60550..61275 | - | 726 | Protein_65 | IS5-like element ISKpn26 family transposase | - |
| HV048_RS22910 | 61340..62095 | - | 756 | WP_038423655.1 | IS21-like element ISEc10 family helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ | 1..77568 | 77568 | |
| - | inside | IScluster/Tn | - | - | 51221..63946 | 12725 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11571.24 Da Isoelectric Point: 6.4650
>T166016 WP_045616569.1 NZ_CP058168:57856-58161 [Enterobacter hormaechei]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHIGDDSYRLMTTDMASVTASVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
>T166016 NZ_CP074019:3970805-3971269 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8321.25 Da Isoelectric Point: 4.5358
>AT166016 WP_016240352.1 NZ_CP058168:57636-57854 [Enterobacter hormaechei]
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW
MKQRITVTIDSDSYQLLKSADVNISGLVNTAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFAEENRDW
Download Length: 219 bp
>AT166016 NZ_CP074019:3970470-3970805 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|