Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4686220..4686836 Replicon chromosome
Accession NZ_CP058167
Organism Enterobacter hormaechei strain RHBSTW-00059

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV048_RS22190 Protein ID WP_080346796.1
Coordinates 4686220..4686591 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV048_RS22195 Protein ID WP_023298920.1
Coordinates 4686594..4686836 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV048_RS22175 4683720..4684622 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV048_RS22180 4684619..4685254 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV048_RS22185 4685251..4686180 + 930 WP_023305104.1 formate dehydrogenase accessory protein FdhE -
HV048_RS22190 4686220..4686591 - 372 WP_080346796.1 type II toxin-antitoxin system VapC family toxin Toxin
HV048_RS22195 4686594..4686836 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV048_RS22200 4687036..4687956 + 921 WP_023305106.1 alpha/beta hydrolase -
HV048_RS22205 4687965..4688906 - 942 WP_180256154.1 fatty acid biosynthesis protein FabY -
HV048_RS22210 4688951..4689388 - 438 WP_023305108.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV048_RS22215 4689385..4690266 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV048_RS22220 4690260..4690859 - 600 WP_023305109.1 glucose-1-phosphatase -
HV048_RS22225 4690978..4691778 - 801 WP_023305110.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13668.73 Da        Isoelectric Point: 6.2151

>T166012 WP_080346796.1 NZ_CP058167:c4686591-4686220 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMEAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T166012 NZ_CP074019:c2767627-2767376 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT166012 WP_023298920.1 NZ_CP058167:c4686836-4686594 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT166012 NZ_CP074019:c2767379-2767125 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References