Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3806162..3806819 Replicon chromosome
Accession NZ_CP058167
Organism Enterobacter hormaechei strain RHBSTW-00059

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag HV048_RS18040 Protein ID WP_022649305.1
Coordinates 3806162..3806572 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV048_RS18045 Protein ID WP_003863437.1
Coordinates 3806553..3806819 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV048_RS18020 3802160..3803893 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
HV048_RS18025 3803899..3804612 - 714 WP_023306885.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV048_RS18030 3804641..3805537 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
HV048_RS18035 3805639..3806160 + 522 WP_023306886.1 flavodoxin FldB -
HV048_RS18040 3806162..3806572 - 411 WP_022649305.1 protein YgfX Toxin
HV048_RS18045 3806553..3806819 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV048_RS18050 3807114..3808094 + 981 WP_023298542.1 tRNA-modifying protein YgfZ -
HV048_RS18055 3808618..3809277 - 660 WP_022649307.1 hemolysin III family protein -
HV048_RS18060 3809544..3810275 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T166011 WP_022649305.1 NZ_CP058167:c3806572-3806162 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T166011 NZ_CP074019:c2767379-2767125 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT166011 WP_003863437.1 NZ_CP058167:c3806819-3806553 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT166011 NZ_CP074019:c2767627-2767376 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References