Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1202170..1202791 Replicon chromosome
Accession NZ_CP058167
Organism Enterobacter hormaechei strain RHBSTW-00059

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV048_RS05810 Protein ID WP_015571250.1
Coordinates 1202170..1202388 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV048_RS05815 Protein ID WP_006809850.1
Coordinates 1202417..1202791 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV048_RS05780 1198182..1198442 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV048_RS05785 1198445..1198585 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV048_RS05790 1198582..1199292 - 711 WP_023305593.1 GNAT family N-acetyltransferase -
HV048_RS05795 1199395..1200855 + 1461 WP_023305594.1 PLP-dependent aminotransferase family protein -
HV048_RS05800 1200827..1201294 - 468 WP_023305595.1 hypothetical protein -
HV048_RS05805 1201411..1201962 - 552 WP_023305596.1 maltose O-acetyltransferase -
HV048_RS05810 1202170..1202388 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV048_RS05815 1202417..1202791 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV048_RS05820 1203301..1206447 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HV048_RS05825 1206470..1207663 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T166001 WP_015571250.1 NZ_CP058167:c1202388-1202170 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T166001 NZ_CP074019:430355-430705 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT166001 WP_006809850.1 NZ_CP058167:c1202791-1202417 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT166001 NZ_CP074019:430110-430361 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References