Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 30733..31267 Replicon plasmid pRHBSTW-00070_2
Accession NZ_CP058165
Organism Enterobacter hormaechei strain RHBSTW-00070

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1V8P2
Locus tag HV054_RS22565 Protein ID WP_000143805.1
Coordinates 30733..31023 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A387K2U4
Locus tag HV054_RS22570 Protein ID WP_032635065.1
Coordinates 31013..31267 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV054_RS22540 26338..26541 + 204 Protein_33 IS6 family transposase -
HV054_RS22545 27034..27618 - 585 WP_001137892.1 TetR family transcriptional regulator -
HV054_RS22550 27618..28856 - 1239 WP_000004159.1 MFS transporter -
HV054_RS22555 28853..29758 - 906 WP_000219391.1 Mph(A) family macrolide 2'-phosphotransferase -
HV054_RS22560 29880..30584 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
HV054_RS22565 30733..31023 - 291 WP_000143805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV054_RS22570 31013..31267 - 255 WP_032635065.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HV054_RS22575 31426..32136 - 711 WP_025760373.1 tyrosine-type recombinase/integrase -
HV054_RS22580 32223..32618 - 396 WP_032672763.1 hypothetical protein -
HV054_RS22585 33386..35215 + 1830 WP_032635064.1 hypothetical protein -
HV054_RS22590 35465..35914 + 450 WP_032635063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / aac(3)-IId / blaTEM-1B / blaSHV-12 - 1..206287 206287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-47)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11463.41 Da        Isoelectric Point: 10.2689

>T165998 WP_000143805.1 NZ_CP058165:c31023-30733 [Enterobacter hormaechei]
MTFNVEFDERAFKEWNKLEKTIREQFKKKLKKLQQNPYVESARLHGDLAGCFKIKLRASGFRLIYKVIDDEIVIWVVAVG
KREDEKAYETARKRLL

Download         Length: 291 bp

>T165998 NZ_CP074013:78918-79196 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGT
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTGCCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCCGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9722.07 Da        Isoelectric Point: 4.4356

>AT165998 WP_032635065.1 NZ_CP058165:c31267-31013 [Enterobacter hormaechei]
MSTIQIRVDDELKKEAYQAFEKLNLSPSDALRLFLRYVAENEKLPFAEVSVMVSEDDEDADILAVVRERLKNPARRIRVN
VDDL

Download         Length: 255 bp

>AT165998 NZ_CP074013:78649-78918 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCAAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1V8P2

Antitoxin

Source ID Structure
AlphaFold DB A0A387K2U4

References