Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1080311..1080932 Replicon chromosome
Accession NZ_CP058164
Organism Enterobacter hormaechei strain RHBSTW-00070

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV054_RS05135 Protein ID WP_015571250.1
Coordinates 1080311..1080529 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV054_RS05140 Protein ID WP_006809850.1
Coordinates 1080558..1080932 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV054_RS05105 1076323..1076583 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV054_RS05110 1076586..1076726 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV054_RS05115 1076723..1077433 - 711 WP_022647267.1 GNAT family N-acetyltransferase -
HV054_RS05120 1077536..1078996 + 1461 WP_022647268.1 PLP-dependent aminotransferase family protein -
HV054_RS05125 1078968..1079435 - 468 WP_022647269.1 hypothetical protein -
HV054_RS05130 1079552..1080103 - 552 WP_022647270.1 maltose O-acetyltransferase -
HV054_RS05135 1080311..1080529 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV054_RS05140 1080558..1080932 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV054_RS05145 1081442..1084588 - 3147 WP_022647271.1 multidrug efflux RND transporter permease subunit -
HV054_RS05150 1084611..1085804 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T165984 WP_015571250.1 NZ_CP058164:c1080529-1080311 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T165984 NZ_CP074012:1063903-1064238 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT165984 WP_006809850.1 NZ_CP058164:c1080932-1080558 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT165984 NZ_CP074012:1063655-1063903 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References