Detailed information of TA system TA165979

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 3968894..3969573
• Replicon: chromosome
• Accession: NZ_CP058160
• Organism: Enterobacter hormaechei strain RHBSTW-00083

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: HV059_RS18990
• Protein ID: WP_160391678.1
• Coordinates: 3968894..3969235 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A8H9RPW5
• Locus tag: HV059_RS18995
• Protein ID: WP_001548170.1
• Coordinates: 3969256..3969573 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV059_RS18970	3964193..3965938	+	1746	WP_003862574.1	DNA primase	-
HV059_RS18975	3966092..3967936	+	1845	WP_006812010.1	RNA polymerase sigma factor RpoD	-
HV059_RS18980	3968026..3968532	-	507	WP_032649590.1	G/U mismatch-specific DNA glycosylase	-
HV059_RS18990	3968894..3969235	-	342	WP_160391678.1	TA system toxin CbtA family protein	Toxin
HV059_RS18995	3969256..3969573	-	318	WP_001548170.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV059_RS19000	3969593..3969814	-	222	WP_007777714.1	DUF987 domain-containing protein	-
HV059_RS19005	3969823..3970299	-	477	WP_000811693.1	RadC family protein	-
HV059_RS19010	3970315..3970773	-	459	WP_047746256.1	antirestriction protein	-
HV059_RS19015	3970871..3971110	-	240	WP_000194654.1	DUF905 domain-containing protein	-
HV059_RS19020	3971187..3971654	-	468	WP_023305531.1	hypothetical protein	-
HV059_RS19025	3971677..3972120	-	444	WP_181238398.1	hypothetical protein	-
HV059_RS19030	3972120..3972356	-	237	WP_001144031.1	hypothetical protein	-
HV059_RS19035	3972397..3973098	-	702	WP_023326104.1	WYL domain-containing protein	-
HV059_RS19040	3973315..3974135	-	821	Protein_3717	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13005.07 Da
• Isoelectric Point: 10.4476

>T165979 WP_160391678.1 NZ_CP058160:c3969235-3968894 [Enterobacter hormaechei]
MKTLPATTQRAAKPCLSPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNSVR

Nucleotide

• Length: 342 bp

>T165979 NZ_CP074012:c633840-633376 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11883.46 Da
• Isoelectric Point: 7.0810

>AT165979 WP_001548170.1 NZ_CP058160:c3969573-3969256 [Enterobacter hormaechei]
MTHINWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRHMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS

Nucleotide

• Length: 318 bp

>AT165979 NZ_CP074012:c634175-633840 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA