Detailed information of TA system TA165977

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 3027238..3029021
• Replicon: chromosome
• Accession: NZ_CP058160
• Organism: Enterobacter hormaechei strain RHBSTW-00083

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV059_RS14555
• Protein ID: WP_047053382.1
• Coordinates: 3027238..3028587 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HV059_RS14560
• Protein ID: WP_047053381.1
• Coordinates: 3028584..3029021 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV059_RS14530	3023061..3023996	-	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-
HV059_RS14535	3024165..3024560	+	396	WP_023295055.1	CidA/LrgA family protein	-
HV059_RS14540	3024557..3025252	+	696	WP_015572322.1	CidB/LrgB family autolysis modulator	-
HV059_RS14545	3025381..3026265	+	885	WP_047053384.1	cytidine deaminase	-
HV059_RS14550	3026393..3027103	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
HV059_RS14555	3027238..3028587	+	1350	WP_047053382.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV059_RS14560	3028584..3029021	+	438	WP_047053381.1	helix-turn-helix domain-containing protein	Antitoxin
HV059_RS14565	3029060..3030070	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
HV059_RS14570	3030086..3031606	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
HV059_RS14575	3031686..3032684	-	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
HV059_RS14580	3032980..3034002	-	1023	WP_047053378.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (78-129)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51132.76 Da
• Isoelectric Point: 4.6556

>T165977 WP_047053382.1 NZ_CP058160:3027238-3028587 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLTCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFHYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T165977 NZ_CP074009:c71585-71298 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGATTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16161.57 Da
• Isoelectric Point: 10.5154

>AT165977 WP_047053381.1 NZ_CP058160:3028584-3029021 [Enterobacter hormaechei]
MKTSNEAESELLQTLAQVRSVNKKRHHDEAEDPDKPSVVKRQRVSQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADIINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT165977 NZ_CP074009:c71833-71582 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA