Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2282451..2283190 Replicon chromosome
Accession NZ_CP058160
Organism Enterobacter hormaechei strain RHBSTW-00083

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag HV059_RS11015 Protein ID WP_045329830.1
Coordinates 2282451..2282936 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag HV059_RS11020 Protein ID WP_047050951.1
Coordinates 2282924..2283190 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV059_RS10995 2278604..2279362 - 759 WP_047050948.1 trans-aconitate 2-methyltransferase -
HV059_RS11000 2279447..2280031 - 585 WP_047050949.1 NUDIX domain-containing protein -
HV059_RS11005 2280118..2280876 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
HV059_RS11010 2280981..2282273 + 1293 WP_047050950.1 glycoside hydrolase -
HV059_RS11015 2282451..2282936 - 486 WP_045329830.1 GNAT family N-acetyltransferase Toxin
HV059_RS11020 2282924..2283190 - 267 WP_047050951.1 DUF1778 domain-containing protein Antitoxin
HV059_RS11025 2283254..2284183 - 930 WP_047050986.1 LysR family transcriptional regulator -
HV059_RS11030 2284313..2285701 + 1389 WP_047050952.1 MFS transporter -
HV059_RS11035 2285723..2286718 - 996 WP_047050954.1 DUF2891 domain-containing protein -
HV059_RS11040 2286728..2287714 - 987 WP_047050955.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17512.18 Da        Isoelectric Point: 9.9658

>T165967 WP_045329830.1 NZ_CP058160:c2282936-2282451 [Enterobacter hormaechei]
VGRVTAPEPLSSAHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T165967 NZ_CP074007:3027946-3028053 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10089.51 Da        Isoelectric Point: 4.4857

>AT165967 WP_047050951.1 NZ_CP058160:c2283190-2282924 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVANDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT165967 NZ_CP074007:c3027897-3027832 [Escherichia coli]
TCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACATGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References