Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 60012..60668 Replicon chromosome
Accession NZ_CP058160
Organism Enterobacter hormaechei strain RHBSTW-00083

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV059_RS00300 Protein ID WP_080344062.1
Coordinates 60276..60668 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV059_RS00295 Protein ID WP_047050676.1
Coordinates 60012..60272 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV059_RS00270 55229..56350 - 1122 WP_047050671.1 efflux RND transporter periplasmic adaptor subunit -
HV059_RS00275 56498..57067 - 570 WP_032103771.1 TetR/AcrR family transcriptional regulator -
HV059_RS00280 57253..57672 + 420 WP_047050673.1 GNAT family N-acetyltransferase -
HV059_RS00285 57669..58316 - 648 WP_017383663.1 TetR/AcrR family transcriptional regulator -
HV059_RS00290 58395..59894 + 1500 WP_047718455.1 MFS transporter -
HV059_RS00295 60012..60272 + 261 WP_047050676.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV059_RS00300 60276..60668 + 393 WP_080344062.1 type II toxin-antitoxin system VapC family toxin Toxin
HV059_RS00305 60737..61210 - 474 WP_032674176.1 hypothetical protein -
HV059_RS00310 61592..62392 + 801 WP_047050678.1 lipoprotein NlpA -
HV059_RS00315 62426..63106 - 681 WP_047050679.1 EAL domain-containing protein -
HV059_RS00320 63182..63802 - 621 WP_047050680.1 response regulator transcription factor -
HV059_RS00325 64373..65008 + 636 WP_047050682.1 LuxR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14585.78 Da        Isoelectric Point: 5.8985

>T165958 WP_080344062.1 NZ_CP058160:60276-60668 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITVCAWDSEAAAIYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTQ

Download         Length: 393 bp

>T165958 NZ_CP074007:1168915-1169322 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10084.38 Da        Isoelectric Point: 9.6899

>AT165958 WP_047050676.1 NZ_CP058160:60012-60272 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKARHRDNFLRMLKETHVPDTFLSKEERNQSYTTR
NPLEGL

Download         Length: 261 bp

>AT165958 NZ_CP074007:1168668-1168934 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References