Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4722687..4723303 Replicon chromosome
Accession NZ_CP058157
Organism Enterobacter hormaechei strain RHBSTW-00086

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV061_RS22555 Protein ID WP_080339264.1
Coordinates 4722687..4723058 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV061_RS22560 Protein ID WP_023298920.1
Coordinates 4723061..4723303 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV061_RS22540 4720187..4721089 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV061_RS22545 4721086..4721721 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV061_RS22550 4721718..4722647 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
HV061_RS22555 4722687..4723058 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
HV061_RS22560 4723061..4723303 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV061_RS22565 4723503..4724423 + 921 WP_063201039.1 alpha/beta hydrolase -
HV061_RS22570 4724432..4725373 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HV061_RS22575 4725418..4725855 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV061_RS22580 4725852..4726733 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV061_RS22585 4726727..4727326 - 600 WP_003861947.1 glucose-1-phosphatase -
HV061_RS22590 4727445..4728245 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T165956 WP_080339264.1 NZ_CP058157:c4723058-4722687 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T165956 NZ_CP074007:447435-447542 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT165956 WP_023298920.1 NZ_CP058157:c4723303-4723061 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT165956 NZ_CP074007:c447387-447321 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References