Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 57972..58634 Replicon chromosome
Accession NZ_CP058157
Organism Enterobacter hormaechei strain RHBSTW-00086

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV061_RS00285 Protein ID WP_174452898.1
Coordinates 58236..58634 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HV061_RS00280 Protein ID WP_046621841.1
Coordinates 57972..58232 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV061_RS00255 53189..54310 - 1122 WP_045308244.1 efflux RND transporter periplasmic adaptor subunit -
HV061_RS00260 54458..55027 - 570 WP_063199780.1 TetR/AcrR family transcriptional regulator -
HV061_RS00265 55213..55632 + 420 WP_022646571.1 GNAT family N-acetyltransferase -
HV061_RS00270 55629..56276 - 648 WP_063199836.1 TetR/AcrR family transcriptional regulator -
HV061_RS00275 56355..57854 + 1500 WP_058646776.1 MFS transporter -
HV061_RS00280 57972..58232 + 261 WP_046621841.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HV061_RS00285 58236..58634 + 399 WP_174452898.1 type II toxin-antitoxin system VapC family toxin Toxin
HV061_RS00290 58824..59624 + 801 WP_058677108.1 lipoprotein NlpA -
HV061_RS00295 59643..60323 - 681 WP_148742205.1 EAL domain-containing protein -
HV061_RS00300 60399..61019 - 621 WP_015570093.1 response regulator transcription factor -
HV061_RS00305 61589..62224 + 636 WP_032622107.1 LuxR family transcriptional regulator -
HV061_RS00310 62231..63295 - 1065 WP_148742203.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14702.88 Da        Isoelectric Point: 5.8985

>T165942 WP_174452898.1 NZ_CP058157:58236-58634 [Enterobacter hormaechei]
MLHMLDTNIVSHLVRQHPEVVNRYSQITPEKMCISSVTEAELLYGVAKKQNNKLHETIMEFLKTITICAWDSEAAATYGE
LRAAMEKKGKVMGDLDQLIAAHAISRGTTIVTNDHAFGMVQDLTVEDWTTAA

Download         Length: 399 bp

>T165942 NZ_CP074005:c758180-757803 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10169.44 Da        Isoelectric Point: 7.0166

>AT165942 WP_046621841.1 NZ_CP058157:57972-58232 [Enterobacter hormaechei]
MERTAKLFKKGRNQAVVLPAEFAFETESVYIRRDDEGNVVLTARSEKERHRDNFLRMLKETYVPDTFLSKEERNQSYTTR
DPLEGL

Download         Length: 261 bp

>AT165942 NZ_CP074005:c758601-758227 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References