Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3969945..3970624 Replicon chromosome
Accession NZ_CP058153
Organism Enterobacter hormaechei strain RHBSTW-00105

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag HV071_RS19000 Protein ID WP_160391678.1
Coordinates 3969945..3970286 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8H9RPW5
Locus tag HV071_RS19005 Protein ID WP_001548170.1
Coordinates 3970307..3970624 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV071_RS18980 3965244..3966989 + 1746 WP_003862574.1 DNA primase -
HV071_RS18985 3967143..3968987 + 1845 WP_006812010.1 RNA polymerase sigma factor RpoD -
HV071_RS18990 3969077..3969583 - 507 WP_032649590.1 G/U mismatch-specific DNA glycosylase -
HV071_RS19000 3969945..3970286 - 342 WP_160391678.1 TA system toxin CbtA family protein Toxin
HV071_RS19005 3970307..3970624 - 318 WP_001548170.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV071_RS19010 3970644..3970865 - 222 WP_007777714.1 DUF987 domain-containing protein -
HV071_RS19015 3970874..3971350 - 477 WP_000811693.1 RadC family protein -
HV071_RS19020 3971366..3971824 - 459 WP_047746256.1 antirestriction protein -
HV071_RS19025 3971922..3972161 - 240 WP_000194654.1 DUF905 domain-containing protein -
HV071_RS19030 3972238..3972705 - 468 WP_023305531.1 hypothetical protein -
HV071_RS19035 3972728..3973171 - 444 WP_181238398.1 hypothetical protein -
HV071_RS19040 3973171..3973407 - 237 WP_001144031.1 hypothetical protein -
HV071_RS19045 3973448..3974149 - 702 WP_023326104.1 WYL domain-containing protein -
HV071_RS19050 3974366..3975186 - 821 Protein_3719 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13005.07 Da        Isoelectric Point: 10.4476

>T165938 WP_160391678.1 NZ_CP058153:c3970286-3969945 [Enterobacter hormaechei]
MKTLPATTQRAAKPCLSPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNSVR

Download         Length: 342 bp

>T165938 NZ_CP074005:189250-189357 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11883.46 Da        Isoelectric Point: 7.0810

>AT165938 WP_001548170.1 NZ_CP058153:c3970624-3970307 [Enterobacter hormaechei]
MTHINWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRHMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS

Download         Length: 318 bp

>AT165938 NZ_CP074005:c189202-189136 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References