Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3753488..3754145 Replicon chromosome
Accession NZ_CP058153
Organism Enterobacter hormaechei strain RHBSTW-00105

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag HV071_RS17950 Protein ID WP_017382887.1
Coordinates 3753488..3753898 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag HV071_RS17955 Protein ID WP_003863437.1
Coordinates 3753879..3754145 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV071_RS17930 3749486..3751219 - 1734 WP_047050807.1 single-stranded-DNA-specific exonuclease RecJ -
HV071_RS17935 3751225..3751938 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV071_RS17940 3751967..3752863 - 897 WP_047050805.1 site-specific tyrosine recombinase XerD -
HV071_RS17945 3752965..3753486 + 522 WP_015571793.1 flavodoxin FldB -
HV071_RS17950 3753488..3753898 - 411 WP_017382887.1 protein YgfX Toxin
HV071_RS17955 3753879..3754145 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
HV071_RS17960 3754440..3755420 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
HV071_RS17965 3755532..3756191 - 660 WP_047050804.1 hemolysin III family protein -
HV071_RS17970 3756458..3757189 + 732 WP_047050802.1 MurR/RpiR family transcriptional regulator -
HV071_RS17975 3757306..3758739 + 1434 WP_023295383.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T165937 WP_017382887.1 NZ_CP058153:c3753898-3753488 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T165937 NZ_CP074002:c104052-103765 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT165937 WP_003863437.1 NZ_CP058153:c3754145-3753879 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT165937 NZ_CP074002:c104291-104052 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAAGCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References