Detailed information of TA system TA165922

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 975933..976642
• Replicon: chromosome
• Accession: NZ_CP058153
• Organism: Enterobacter hormaechei strain RHBSTW-00105

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7D6YAQ1
• Locus tag: HV071_RS04665
• Protein ID: WP_071886833.1
• Coordinates: 976274..976642 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HV071_RS04660
• Protein ID: WP_047051179.1
• Coordinates: 975933..976253 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV071_RS04620	971493..972327	+	835	Protein_890	DUF945 domain-containing protein	-
HV071_RS04625	972529..973233	+	705	WP_047051185.1	WYL domain-containing protein	-
HV071_RS04630	973230..973844	+	615	WP_047051184.1	hypothetical protein	-
HV071_RS04635	973933..974343	+	411	WP_047051183.1	hypothetical protein	-
HV071_RS04640	974420..974656	+	237	WP_047051182.1	DUF905 domain-containing protein	-
HV071_RS04645	974736..975194	+	459	WP_047051181.1	antirestriction protein	-
HV071_RS04650	975203..975685	+	483	WP_075211782.1	DNA repair protein RadC	-
HV071_RS04655	975694..975915	+	222	WP_016243789.1	DUF987 domain-containing protein	-
HV071_RS04660	975933..976253	+	321	WP_047051179.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV071_RS04665	976274..976642	+	369	WP_071886833.1	TA system toxin CbtA family protein	Toxin
HV071_RS04670	976988..977734	-	747	WP_047051178.1	class I SAM-dependent methyltransferase	-
HV071_RS04675	977745..978002	-	258	WP_003863178.1	YjhX family toxin	-
HV071_RS04680	978262..980199	-	1938	WP_047051177.1	bifunctional diguanylate cyclase/phosphodiesterase	-
HV071_RS04685	980217..980723	-	507	WP_181238541.1	oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	941104..976642	35538
	-	flank	IS/Tn	-	-	980847..981827	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (6-105)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13738.90 Da
• Isoelectric Point: 8.1347

>T165922 WP_071886833.1 NZ_CP058153:976274-976642 [Enterobacter hormaechei]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDQTVIQEHIDAGITLANAVNFLVEKYELVRIDRTGF
TSQEQAPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

>T165922 NZ_CP074001:814293-814700 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11901.60 Da
• Isoelectric Point: 7.2633

>AT165922 WP_047051179.1 NZ_CP058153:975933-976253 [Enterobacter hormaechei]
MRSNATWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECLKLDVAFPHFISLMESMLTTGEMNPRHAHCVTLY
RNGFTCEADTLGSCGYLYIVVYPTQS

Nucleotide

• Length: 321 bp

>AT165922 NZ_CP074001:814046-814312 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A7D6YAQ1