Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4717443..4718059 Replicon chromosome
Accession NZ_CP058149
Organism Enterobacter hormaechei strain RHBSTW-00114

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV076_RS22685 Protein ID WP_080339264.1
Coordinates 4717443..4717814 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV076_RS22690 Protein ID WP_023298920.1
Coordinates 4717817..4718059 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV076_RS22670 4714943..4715845 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV076_RS22675 4715842..4716477 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV076_RS22680 4716474..4717403 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
HV076_RS22685 4717443..4717814 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
HV076_RS22690 4717817..4718059 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV076_RS22695 4718259..4719179 + 921 WP_045620872.1 alpha/beta hydrolase -
HV076_RS22700 4719188..4720129 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HV076_RS22705 4720174..4720611 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV076_RS22710 4720608..4721489 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV076_RS22715 4721483..4722082 - 600 WP_045620871.1 glucose-1-phosphatase -
HV076_RS22720 4722201..4723001 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T165914 WP_080339264.1 NZ_CP058149:c4717814-4717443 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T165914 NZ_CP073996:3900077-3900475 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT165914 WP_023298920.1 NZ_CP058149:c4718059-4717817 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT165914 NZ_CP073996:3899781-3900074 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References