Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1110053..1110674 Replicon chromosome
Accession NZ_CP058149
Organism Enterobacter hormaechei strain RHBSTW-00114

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV076_RS05355 Protein ID WP_015571250.1
Coordinates 1110053..1110271 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV076_RS05360 Protein ID WP_006809850.1
Coordinates 1110300..1110674 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV076_RS05325 1106065..1106325 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV076_RS05330 1106328..1106468 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV076_RS05335 1106465..1107175 - 711 WP_045622295.1 GNAT family N-acetyltransferase -
HV076_RS05340 1107278..1108738 + 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
HV076_RS05345 1108710..1109177 - 468 WP_045622293.1 membrane protein -
HV076_RS05350 1109294..1109845 - 552 WP_045622291.1 maltose O-acetyltransferase -
HV076_RS05355 1110053..1110271 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV076_RS05360 1110300..1110674 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV076_RS05365 1111184..1114330 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
HV076_RS05370 1114353..1115546 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T165902 WP_015571250.1 NZ_CP058149:c1110271-1110053 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T165902 NZ_CP073996:c1672663-1672265 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT165902 WP_006809850.1 NZ_CP058149:c1110674-1110300 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT165902 NZ_CP073996:c1672890-1672663 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References