Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yfjZ/CbtA-CbeA |
| Location | 4194801..4195480 | Replicon | chromosome |
| Accession | NZ_CP058146 | ||
| Organism | Enterobacter hormaechei strain RHBSTW-00133 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | R8WLP2 |
| Locus tag | HV088_RS20230 | Protein ID | WP_006812012.1 |
| Coordinates | 4194801..4195142 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | R8WMM2 |
| Locus tag | HV088_RS20235 | Protein ID | WP_006812013.1 |
| Coordinates | 4195163..4195480 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HV088_RS20185 | 4190009..4190236 | - | 228 | WP_032634595.1 | TraR/DksA family transcriptional regulator | - |
| HV088_RS20190 | 4190236..4190469 | - | 234 | WP_181236547.1 | DUF2732 domain-containing protein | - |
| HV088_RS20195 | 4190537..4190878 | - | 342 | WP_032610572.1 | DUF5347 domain-containing protein | - |
| HV088_RS20200 | 4190842..4191042 | - | 201 | WP_015386352.1 | DUF2724 domain-containing protein | - |
| HV088_RS20205 | 4191050..4191559 | - | 510 | WP_015386351.1 | phage regulatory CII family protein | - |
| HV088_RS20210 | 4191594..4191830 | - | 237 | WP_015386350.1 | hypothetical protein | - |
| HV088_RS20215 | 4191932..4192546 | + | 615 | WP_032610574.1 | phage repressor protein CI | - |
| HV088_RS20220 | 4192558..4193457 | + | 900 | WP_032610575.1 | NAD-dependent DNA ligase | - |
| HV088_RS20225 | 4193467..4194480 | + | 1014 | WP_032610576.1 | tyrosine-type recombinase/integrase | - |
| HV088_RS20230 | 4194801..4195142 | - | 342 | WP_006812012.1 | TA system toxin CbtA family protein | Toxin |
| HV088_RS20235 | 4195163..4195480 | - | 318 | WP_006812013.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HV088_RS20240 | 4195500..4195721 | - | 222 | WP_000691995.1 | DUF987 domain-containing protein | - |
| HV088_RS20245 | 4195730..4196206 | - | 477 | WP_047355118.1 | RadC family protein | - |
| HV088_RS20250 | 4196222..4196680 | - | 459 | WP_112020495.1 | antirestriction protein | - |
| HV088_RS20255 | 4196783..4197022 | - | 240 | WP_112020496.1 | DUF905 domain-containing protein | - |
| HV088_RS20260 | 4197099..4197566 | - | 468 | WP_063841896.1 | hypothetical protein | - |
| HV088_RS20265 | 4197589..4198032 | - | 444 | WP_001547764.1 | phage transcriptional regulator | - |
| HV088_RS20270 | 4198032..4198268 | - | 237 | WP_001115854.1 | hypothetical protein | - |
| HV088_RS20275 | 4198305..4199006 | - | 702 | WP_008324530.1 | WYL domain-containing protein | - |
| HV088_RS20280 | 4199224..4200045 | - | 822 | WP_097535357.1 | DUF945 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4156623..4200045 | 43422 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12989.07 Da Isoelectric Point: 10.4476
>T165899 WP_006812012.1 NZ_CP058146:c4195142-4194801 [Enterobacter hormaechei]
MKTLPATTQRAAKPCLAPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNSVR
MKTLPATTQRAAKPCLAPVAVWQMLLTRLLKQHYGLTLNDTPFSEERVIQEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQATGLLRQSRKNSVR
Download Length: 342 bp
>T165899 NZ_CP073996:c984275-984172 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 106 a.a. Molecular weight: 11874.45 Da Isoelectric Point: 7.0166
>AT165899 WP_006812013.1 NZ_CP058146:c4195480-4195163 [Enterobacter hormaechei]
MTHINWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS
MTHINWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS
Download Length: 318 bp
>AT165899 NZ_CP073996:984134-984405 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|