Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1072963..1073584 Replicon chromosome
Accession NZ_CP058146
Organism Enterobacter hormaechei strain RHBSTW-00133

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag HV088_RS05075 Protein ID WP_015571250.1
Coordinates 1072963..1073181 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag HV088_RS05080 Protein ID WP_006809850.1
Coordinates 1073210..1073584 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV088_RS05045 1068975..1069235 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
HV088_RS05050 1069238..1069378 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV088_RS05055 1069375..1070085 - 711 WP_045622295.1 GNAT family N-acetyltransferase -
HV088_RS05060 1070188..1071648 + 1461 WP_023299463.1 PLP-dependent aminotransferase family protein -
HV088_RS05065 1071620..1072087 - 468 WP_045622293.1 membrane protein -
HV088_RS05070 1072204..1072755 - 552 WP_045622291.1 maltose O-acetyltransferase -
HV088_RS05075 1072963..1073181 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
HV088_RS05080 1073210..1073584 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
HV088_RS05085 1074094..1077240 - 3147 WP_181236566.1 multidrug efflux RND transporter permease subunit AcrB -
HV088_RS05090 1077263..1078456 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T165888 WP_015571250.1 NZ_CP058146:c1073181-1072963 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T165888 NZ_CP073994:3493933-3494151 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT165888 WP_006809850.1 NZ_CP058146:c1073584-1073210 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT165888 NZ_CP073994:3493533-3493907 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References