Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2038..2585 Replicon plasmid pRHBSTW-00138_8
Accession NZ_CP058138
Organism Klebsiella quasipneumoniae strain RHBSTW-00138

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2W0G5G9
Locus tag HV092_RS27935 Protein ID WP_037427062.1
Coordinates 2277..2585 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A663ALK6
Locus tag HV092_RS27930 Protein ID WP_064179603.1
Coordinates 2038..2277 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV092_RS27920 96..845 - 750 WP_074192387.1 toll/interleukin-1 receptor domain-containing protein -
HV092_RS27925 827..1756 - 930 WP_064179607.1 replication initiation protein -
HV092_RS27930 2038..2277 + 240 WP_064179603.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
HV092_RS27935 2277..2585 + 309 WP_037427062.1 CcdB family protein Toxin
HV092_RS27940 2689..2925 - 237 WP_037427059.1 MbeD family mobilization/exclusion protein -
HV092_RS27945 2986..3471 - 486 WP_064179604.1 MbeB family mobilization protein -
HV092_RS27950 3443..4195 - 753 Protein_6 relaxase/mobilization nuclease domain-containing protein -
HV092_RS27955 4140..4475 - 336 WP_074192386.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4618 4618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11792.44 Da        Isoelectric Point: 4.6135

>T165886 WP_037427062.1 NZ_CP058138:2277-2585 [Klebsiella quasipneumoniae]
MQFMVYRNNSNNRAYPYLLDVQSDIIDELNTRLVIPLFLLDEVNGRPARRLTPVLNVDGEDFLVMTHEMASVRQSQLGEE
VVSVREHRQAIKNALDFLLDGF

Download         Length: 309 bp

>T165886 NZ_CP073994:2694674-2694781 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9025.29 Da        Isoelectric Point: 10.5889

>AT165886 WP_064179603.1 NZ_CP058138:2038-2277 [Klebsiella quasipneumoniae]
MPVSAMRHKKTVSVTIEPALLHQAREAGINLSATLTTALKHQIRESEAERWKRANRKAIQELNRITDEHGLLSDDHRTF

Download         Length: 240 bp

>AT165886 NZ_CP073994:c2694627-2694561 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G5G9

Antitoxin

Source ID Structure
AlphaFold DB A0A663ALK6

References