Detailed information of TA system TA165880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4775822..4776335
• Replicon: chromosome
• Accession: NZ_CP058131
• Organism: Klebsiella quasipneumoniae strain RHBSTW-00138

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HV092_RS23455
• Protein ID: WP_181351864.1
• Coordinates: 4775822..4776103 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: HV092_RS23460
• Protein ID: WP_002886901.1
• Coordinates: 4776093..4776335 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV092_RS23445	4772833..4774971	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
HV092_RS23450	4775354..4775818	+	465	WP_032456904.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HV092_RS23455	4775822..4776103	-	282	WP_181351864.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HV092_RS23460	4776093..4776335	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HV092_RS23465	4776413..4778323	-	1911	WP_181351865.1	BglG family transcription antiterminator	-
HV092_RS23470	4778346..4779497	-	1152	WP_181351866.1	lactonase family protein	-
HV092_RS23475	4779565..4780305	-	741	WP_181351867.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11066.88 Da
• Isoelectric Point: 10.4123

>T165880 WP_181351864.1 NZ_CP058131:c4776103-4775822 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKPQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T165880 NZ_CP058131:c4776103-4775822 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGCTTGGCGAGACGGTCAAAAAACAGTTCAAAAA
TAAGCCCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCAAGC
TTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTGCGAGATAGGGTGGTGGTGGTTTACGTTATTGCCATTGGCAAAAGA
GAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT165880 WP_002886901.1 NZ_CP058131:c4776335-4776093 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT165880 NZ_CP058131:c4776335-4776093 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGGCTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0