Detailed information of TA system TA165879

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4265418..4266172
• Replicon: chromosome
• Accession: NZ_CP058131
• Organism: Klebsiella quasipneumoniae strain RHBSTW-00138

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A377E3D6
• Locus tag: HV092_RS21030
• Protein ID: WP_001194695.1
• Coordinates: 4265795..4266172 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HV092_RS21025
• Protein ID: WP_165688905.1
• Coordinates: 4265418..4265744 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV092_RS20980	4260624..4261076	+	453	WP_001020418.1	hypothetical protein	-
HV092_RS20985	4261073..4261525	+	453	WP_000734138.1	hypothetical protein	-
HV092_RS20990	4261588..4262130	+	543	WP_001104018.1	DUF4339 domain-containing protein	-
HV092_RS20995	4262190..4262642	+	453	WP_001061894.1	hypothetical protein	-
HV092_RS21000	4262719..4262952	+	234	WP_001114682.1	DUF905 domain-containing protein	-
HV092_RS21005	4263072..4263890	+	819	WP_001234406.1	DUF945 domain-containing protein	-
HV092_RS21010	4264158..4264628	+	471	WP_181351779.1	antirestriction protein	-
HV092_RS21015	4264640..4265119	+	480	WP_061355964.1	DNA repair protein RadC	-
HV092_RS21020	4265140..4265361	+	222	WP_000691981.1	DUF987 domain-containing protein	-
HV092_RS21025	4265418..4265744	+	327	WP_165688905.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HV092_RS21030	4265795..4266172	+	378	WP_001194695.1	TA system toxin CbtA family protein	Toxin
HV092_RS21035	4266169..4266660	+	492	WP_000777682.1	hypothetical protein	-
HV092_RS21040	4266692..4266895	+	204	WP_000413747.1	DUF957 domain-containing protein	-
HV092_RS21045	4266976..4267820	+	845	Protein_4131	DUF4942 domain-containing protein	-
HV092_RS21055	4268163..4268903	-	741	WP_012968891.1	DNA polymerase III subunit epsilon	-
HV092_RS21060	4268959..4269426	+	468	WP_004204620.1	ribonuclease HI	-
HV092_RS21065	4269423..4270145	-	723	WP_004204619.1	class I SAM-dependent methyltransferase	-
HV092_RS21070	4270178..4270933	+	756	WP_004204618.1	hydroxyacylglutathione hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14180.97 Da
• Isoelectric Point: 7.4209

>T165879 WP_001194695.1 NZ_CP058131:4265795-4266172 [Klebsiella quasipneumoniae]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR

Nucleotide

• Length: 378 bp

>T165879 NZ_CP073994:1099226-1099537 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11889.62 Da
• Isoelectric Point: 6.9453

>AT165879 WP_165688905.1 NZ_CP058131:4265418-4265744 [Klebsiella quasipneumoniae]
ITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELTPRHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA

Nucleotide

• Length: 327 bp

>AT165879 NZ_CP073994:1099534-1099953 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A377E3D6