Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4017608..4018227 Replicon chromosome
Accession NZ_CP058131
Organism Klebsiella quasipneumoniae strain RHBSTW-00138

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HV092_RS19790 Protein ID WP_002892050.1
Coordinates 4018009..4018227 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HV092_RS19785 Protein ID WP_002892066.1
Coordinates 4017608..4017982 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV092_RS19775 4012761..4013954 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV092_RS19780 4013977..4017123 + 3147 WP_057213706.1 multidrug efflux RND transporter permease subunit AcrB -
HV092_RS19785 4017608..4017982 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HV092_RS19790 4018009..4018227 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HV092_RS19795 4018385..4018951 + 567 WP_064187828.1 maltose O-acetyltransferase -
HV092_RS19800 4018923..4019045 - 123 WP_032426076.1 hypothetical protein -
HV092_RS19805 4019088..4019558 + 471 WP_004204751.1 YlaC family protein -
HV092_RS19810 4019527..4020984 - 1458 WP_181351748.1 PLP-dependent aminotransferase family protein -
HV092_RS19815 4021085..4021783 + 699 WP_023319857.1 GNAT family N-acetyltransferase -
HV092_RS19820 4021780..4021920 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HV092_RS19825 4021920..4022183 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T165878 WP_002892050.1 NZ_CP058131:4018009-4018227 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T165878 NZ_CP073994:1031627-1031962 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT165878 WP_002892066.1 NZ_CP058131:4017608-4017982 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT165878 NZ_CP073994:1031379-1031627 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References