Detailed information of TA system TA165876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2635695..2637283
• Replicon: chromosome
• Accession: NZ_CP058131
• Organism: Klebsiella quasipneumoniae strain RHBSTW-00138

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HV092_RS12990
• Protein ID: WP_181352551.1
• Coordinates: 2635695..2637017 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2A5MFC9
• Locus tag: HV092_RS12995
• Protein ID: WP_004205921.1
• Coordinates: 2637017..2637283 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HV092_RS12965	2632518..2632766	+	249	WP_004205912.1	hypothetical protein	-
HV092_RS12970	2633057..2633275	+	219	WP_002904808.1	ParD-like family protein	-
HV092_RS12975	2633256..2634038	+	783	WP_023318215.1	type I methionyl aminopeptidase	-
HV092_RS12980	2634128..2634244	+	117	Protein_2539	helix-turn-helix domain-containing protein	-
HV092_RS12985	2634386..2635678	+	1293	WP_099441800.1	glycoside hydrolase family 10 protein	-
HV092_RS12990	2635695..2637017	-	1323	WP_181352551.1	type II toxin-antitoxin system HipA family toxin	Toxin
HV092_RS12995	2637017..2637283	-	267	WP_004205921.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HV092_RS13000	2637566..2637892	-	327	WP_023318212.1	hydroxyisourate hydrolase	-
HV092_RS13005	2637889..2638389	-	501	WP_004205925.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HV092_RS13010	2638367..2639746	-	1380	WP_181352552.1	purine permease	-
HV092_RS13015	2640092..2641246	+	1155	WP_115385004.1	FAD-dependent urate hydroxylase HpxO	-
HV092_RS13020	2641227..2642150	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49051.36 Da
• Isoelectric Point: 8.5966

>T165876 WP_181352551.1 NZ_CP058131:c2637017-2635695 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAYLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAG

Nucleotide

• Length: 1323 bp

>T165876 NZ_CP073994:754365-754661 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9940.38 Da
• Isoelectric Point: 7.1997

>AT165876 WP_004205921.1 NZ_CP058131:c2637283-2637017 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT165876 NZ_CP073994:754663-755058 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A5MFC9