Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 821742..822399 Replicon chromosome
Accession NZ_CP058131
Organism Klebsiella quasipneumoniae strain RHBSTW-00138

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HV092_RS04075 Protein ID WP_002916310.1
Coordinates 821989..822399 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HV092_RS04070 Protein ID WP_002916312.1
Coordinates 821742..822008 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV092_RS04045 816847..818280 - 1434 WP_049004121.1 6-phospho-beta-glucosidase BglA -
HV092_RS04050 818399..819127 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
HV092_RS04055 819177..819488 + 312 WP_181352181.1 N(4)-acetylcytidine aminohydrolase -
HV092_RS04060 819651..820310 + 660 WP_004205319.1 hemolysin III family protein -
HV092_RS04065 820513..821496 - 984 WP_181352182.1 tRNA-modifying protein YgfZ -
HV092_RS04070 821742..822008 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HV092_RS04075 821989..822399 + 411 WP_002916310.1 protein YgfX Toxin
HV092_RS04080 822406..822927 - 522 WP_130939397.1 flavodoxin FldB -
HV092_RS04085 823028..823924 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HV092_RS04090 823947..824660 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HV092_RS04095 824666..826399 + 1734 WP_117124558.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T165867 WP_002916310.1 NZ_CP058131:821989-822399 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T165867 NZ_CP073988:2600604-2600711 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT165867 WP_002916312.1 NZ_CP058131:821742-822008 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165867 NZ_CP073988:c2600557-2600491 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References