Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4781602..4782218 Replicon chromosome
Accession NZ_CP058128
Organism Enterobacter hormaechei strain RHBSTW-00140

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HV094_RS23080 Protein ID WP_080339264.1
Coordinates 4781602..4781973 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag HV094_RS23085 Protein ID WP_023298920.1
Coordinates 4781976..4782218 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV094_RS23065 4779102..4780004 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
HV094_RS23070 4780001..4780636 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
HV094_RS23075 4780633..4781562 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
HV094_RS23080 4781602..4781973 - 372 WP_080339264.1 type II toxin-antitoxin system VapC family toxin Toxin
HV094_RS23085 4781976..4782218 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
HV094_RS23090 4782418..4783338 + 921 WP_045620872.1 alpha/beta hydrolase -
HV094_RS23095 4783347..4784288 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
HV094_RS23100 4784333..4784770 - 438 WP_015569909.1 D-tyrosyl-tRNA(Tyr) deacylase -
HV094_RS23105 4784767..4785648 - 882 WP_023298923.1 virulence factor BrkB family protein -
HV094_RS23110 4785642..4786241 - 600 WP_045620871.1 glucose-1-phosphatase -
HV094_RS23115 4786360..4787160 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-114)

Antitoxin

(12-49)


Sequences


Toxin        


Download         Length: 124 a.a.        Molecular weight: 13596.66 Da        Isoelectric Point: 6.4866

>T165865 WP_080339264.1 NZ_CP058128:c4781973-4781602 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

>T165865 NZ_CP073988:c2397586-2397410 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT165865 WP_023298920.1 NZ_CP058128:c4782218-4781976 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT165865 NZ_CP073988:c2397364-2396948 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References