Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 4781602..4782218 | Replicon | chromosome |
Accession | NZ_CP058128 | ||
Organism | Enterobacter hormaechei strain RHBSTW-00140 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | HV094_RS23080 | Protein ID | WP_080339264.1 |
Coordinates | 4781602..4781973 (-) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A9E7BIL4 |
Locus tag | HV094_RS23085 | Protein ID | WP_023298920.1 |
Coordinates | 4781976..4782218 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV094_RS23065 | 4779102..4780004 | + | 903 | WP_003861960.1 | formate dehydrogenase subunit beta | - |
HV094_RS23070 | 4780001..4780636 | + | 636 | WP_006808711.1 | formate dehydrogenase cytochrome b556 subunit | - |
HV094_RS23075 | 4780633..4781562 | + | 930 | WP_022649835.1 | formate dehydrogenase accessory protein FdhE | - |
HV094_RS23080 | 4781602..4781973 | - | 372 | WP_080339264.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
HV094_RS23085 | 4781976..4782218 | - | 243 | WP_023298920.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
HV094_RS23090 | 4782418..4783338 | + | 921 | WP_045620872.1 | alpha/beta hydrolase | - |
HV094_RS23095 | 4783347..4784288 | - | 942 | WP_022649838.1 | fatty acid biosynthesis protein FabY | - |
HV094_RS23100 | 4784333..4784770 | - | 438 | WP_015569909.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
HV094_RS23105 | 4784767..4785648 | - | 882 | WP_023298923.1 | virulence factor BrkB family protein | - |
HV094_RS23110 | 4785642..4786241 | - | 600 | WP_045620871.1 | glucose-1-phosphatase | - |
HV094_RS23115 | 4786360..4787160 | - | 801 | WP_023298924.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13596.66 Da Isoelectric Point: 6.4866
>T165865 WP_080339264.1 NZ_CP058128:c4781973-4781602 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEAKTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL
Download Length: 372 bp
>T165865 NZ_CP073988:c2397586-2397410 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9467.74 Da Isoelectric Point: 4.3775
>AT165865 WP_023298920.1 NZ_CP058128:c4782218-4781976 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW
Download Length: 243 bp
>AT165865 NZ_CP073988:c2397364-2396948 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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