Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1849747..1850518 Replicon chromosome
Accession NZ_CP058118
Organism Klebsiella michiganensis strain RHBSTW-00167

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV105_RS08970 Protein ID WP_044349763.1
Coordinates 1850129..1850518 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV105_RS08965 Protein ID WP_181015783.1
Coordinates 1849747..1850073 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV105_RS08935 1846192..1846824 - 633 WP_072032909.1 inovirus Gp2 family protein -
HV105_RS08940 1847362..1848186 + 825 WP_065805884.1 DUF945 domain-containing protein -
HV105_RS08945 1848183..1848440 + 258 WP_044349282.1 DUF905 domain-containing protein -
HV105_RS08950 1848520..1848963 + 444 WP_044349771.1 antirestriction protein -
HV105_RS08955 1848975..1849454 + 480 WP_044349769.1 DNA repair protein RadC -
HV105_RS08960 1849468..1849689 + 222 WP_044349767.1 DUF987 domain-containing protein -
HV105_RS08965 1849747..1850073 + 327 WP_181015783.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV105_RS08970 1850129..1850518 + 390 WP_044349763.1 TA system toxin CbtA family protein Toxin
HV105_RS08975 1850605..1851450 + 846 WP_044349761.1 DUF4942 domain-containing protein -
HV105_RS08980 1852095..1852642 + 548 Protein_1758 FMN-binding negative transcriptional regulator -
HV105_RS08985 1852987..1854192 + 1206 WP_181250630.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14262.19 Da        Isoelectric Point: 9.5909

>T165837 WP_044349763.1 NZ_CP058118:1850129-1850518 [Klebsiella michiganensis]
MQTKSSPLARAASSRPSPTGVWQALLTSLLEHHYGLTLSDTPFSDEQVIQQHIDAGISLVDALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTATTRGQHTQVSAPGKR

Download         Length: 390 bp

>T165837 NZ_CP073984:1022478-1022813 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12053.74 Da        Isoelectric Point: 6.3101

>AT165837 WP_181015783.1 NZ_CP058118:1849747-1850073 [Klebsiella michiganensis]
ISEPWWGLRCSASPCFGARLVQEGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELNPRHQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Download         Length: 327 bp

>AT165837 NZ_CP073984:1022230-1022478 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References