Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 895868..896640 Replicon chromosome
Accession NZ_CP058118
Organism Klebsiella michiganensis strain RHBSTW-00167

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HV105_RS04290 Protein ID WP_031285565.1
Coordinates 895868..896257 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HV105_RS04295 Protein ID WP_176386959.1
Coordinates 896314..896640 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV105_RS04270 891148..892518 - 1371 WP_181250447.1 cystathionine beta-synthase -
HV105_RS04275 892552..892794 + 243 WP_004854184.1 hypothetical protein -
HV105_RS04280 893064..894452 + 1389 WP_004854182.1 DASS family sodium-coupled anion symporter -
HV105_RS04285 894938..895795 - 858 WP_021314411.1 DUF4942 domain-containing protein -
HV105_RS04290 895868..896257 - 390 WP_031285565.1 TA system toxin CbtA family protein Toxin
HV105_RS04295 896314..896640 - 327 WP_176386959.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HV105_RS04300 896698..896919 - 222 WP_021314408.1 DUF987 domain-containing protein -
HV105_RS04305 896933..897412 - 480 WP_021314407.1 DNA repair protein RadC -
HV105_RS04310 897424..897867 - 444 WP_021314406.1 antirestriction protein -
HV105_RS04315 897947..898195 - 249 WP_021314405.1 DUF905 domain-containing protein -
HV105_RS04320 898201..899025 - 825 WP_049090444.1 DUF945 domain-containing protein -
HV105_RS04325 899567..900109 + 543 WP_181250448.1 inovirus Gp2 family protein -
HV105_RS04330 900125..900991 - 867 Protein_846 IS3 family transposase -
HV105_RS04335 900981..901355 + 375 Protein_847 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-102)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14393.53 Da        Isoelectric Point: 8.9817

>T165833 WP_031285565.1 NZ_CP058118:c896257-895868 [Klebsiella michiganensis]
MQTKSSPLMRAASSRPSPVSVWQTLLTCLLEQHYGLTLSDTPFIDEQVIQQHIDAGISLADALNFIVEKYELVRTDRPGF
SILTQSPFITPIDILRARKATGLMNRDTYKEVTAITRGQHPQVSAPGKR

Download         Length: 390 bp

>T165833 NZ_CP073984:268528-268758 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12241.90 Da        Isoelectric Point: 6.3129

>AT165833 WP_176386959.1 NZ_CP058118:c896640-896314 [Klebsiella michiganensis]
ISEPWWGLRRSVSPCFGARQVQEGNHLHYLADRANFNGQFCDADLRHLDQGFPVLMKQLELMLTSGELNPRYQHCVTLYA
KGLTCEADTLGSHGYVYIAIYPIPVTTE

Download         Length: 327 bp

>AT165833 NZ_CP073984:268755-269114 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References