Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4412661..4413280 Replicon chromosome
Accession NZ_CP058112
Organism Klebsiella grimontii strain RHBSTW-00181

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag HV112_RS21140 Protein ID WP_004099646.1
Coordinates 4413062..4413280 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag HV112_RS21135 Protein ID WP_004129911.1
Coordinates 4412661..4413035 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV112_RS21125 4407830..4409023 + 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HV112_RS21130 4409046..4412192 + 3147 WP_004848339.1 multidrug efflux RND transporter permease subunit -
HV112_RS21135 4412661..4413035 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
HV112_RS21140 4413062..4413280 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
HV112_RS21145 4413442..4414008 + 567 WP_004136050.1 maltose O-acetyltransferase -
HV112_RS21150 4414135..4414605 + 471 WP_004136048.1 YlaC family protein -
HV112_RS21155 4414580..4416034 - 1455 WP_024359024.1 PLP-dependent aminotransferase family protein -
HV112_RS21160 4416135..4416833 + 699 WP_064342287.1 GNAT family N-acetyltransferase -
HV112_RS21165 4416830..4416970 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HV112_RS21170 4416970..4417233 - 264 WP_004129897.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T165828 WP_004099646.1 NZ_CP058112:4413062-4413280 [Klebsiella grimontii]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T165828 NZ_CP073981:c4115764-4115477 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT165828 WP_004129911.1 NZ_CP058112:4412661-4413035 [Klebsiella grimontii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT165828 NZ_CP073981:c4116003-4115764 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References