Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 30812..31413 Replicon plasmid pRHB02-C22_3
Accession NZ_CP058059
Organism Escherichia fergusonii strain RHB02-C22

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag HVV54_RS23545 Protein ID WP_001216045.1
Coordinates 31033..31413 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HVV54_RS23540 Protein ID WP_181465529.1
Coordinates 30812..31033 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV54_RS23530 27796..29076 - 1281 WP_113449347.1 restriction endonuclease subunit S -
HVV54_RS23535 29073..30629 - 1557 WP_181465530.1 type I restriction-modification system subunit M -
HVV54_RS23540 30812..31033 + 222 WP_181465529.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HVV54_RS23545 31033..31413 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HVV54_RS23550 31418..31597 + 180 WP_001339207.1 hypothetical protein -
HVV54_RS23555 31625..32668 + 1044 WP_069187067.1 DUF968 domain-containing protein -
HVV54_RS23560 32757..33209 + 453 WP_001326849.1 late promoter-activating protein -
HVV54_RS23565 33295..34488 + 1194 WP_096321055.1 terminase -
HVV54_RS23570 34488..35972 + 1485 WP_096321054.1 terminase -
HVV54_RS23575 36194..36313 + 120 WP_071594056.1 ash family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94718 94718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T165816 WP_001216045.1 NZ_CP058059:31033-31413 [Escherichia fergusonii]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T165816 NZ_CP073981:1810297-1810404 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTTGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8103.07 Da        Isoelectric Point: 4.7708

>AT165816 WP_181465529.1 NZ_CP058059:30812-31033 [Escherichia fergusonii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDALDSTNKELVNR

Download         Length: 222 bp

>AT165816 NZ_CP073981:c1810249-1810183 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure

References