Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1986..2533 Replicon plasmid pRHB02-C22_2
Accession NZ_CP058058
Organism Escherichia fergusonii strain RHB02-C22

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag HVV54_RS22710 Protein ID WP_000969996.1
Coordinates 2252..2533 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag HVV54_RS22705 Protein ID WP_000079928.1
Coordinates 1986..2255 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV54_RS22695 46..1077 + 1032 WP_000907875.1 replication initiation protein -
HVV54_RS22700 1773..1931 + 159 WP_000841008.1 hypothetical protein -
HVV54_RS22705 1986..2255 + 270 WP_000079928.1 hypothetical protein Antitoxin
HVV54_RS22710 2252..2533 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVV54_RS22715 2573..3421 + 849 WP_001057996.1 3'-5' exonuclease -
HVV54_RS22720 3739..4392 + 654 Protein_5 helix-turn-helix domain-containing protein -
HVV54_RS22725 4401..5261 + 861 WP_000493383.1 EamA family transporter -
HVV54_RS22730 5293..6492 - 1200 WP_000804064.1 tetracycline efflux MFS transporter Tet(A) -
HVV54_RS22735 6598..7248 + 651 WP_181465513.1 tetracycline resistance transcriptional repressor TetR(A) -
HVV54_RS22740 7280..7522 - 243 WP_000844627.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / aadA2 / cmlA1 / ant(3'')-Ia / sul3 - 1..116881 116881
- flank IS/Tn tet(A) - 5293..9506 4213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T165811 WP_000969996.1 NZ_CP058058:2252-2533 [Escherichia fergusonii]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T165811 NZ_CP073981:c625262-624864 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT165811 WP_000079928.1 NZ_CP058058:1986-2255 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT165811 NZ_CP073981:c625558-625265 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References