Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3292653..3293272 Replicon chromosome
Accession NZ_CP058057
Organism Escherichia fergusonii strain RHB02-C22

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HVV54_RS15980 Protein ID WP_001280991.1
Coordinates 3293054..3293272 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag HVV54_RS15975 Protein ID WP_000344803.1
Coordinates 3292653..3293027 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV54_RS15965 3287785..3288978 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HVV54_RS15970 3289001..3292150 + 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
HVV54_RS15975 3292653..3293027 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
HVV54_RS15980 3293054..3293272 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
HVV54_RS15985 3293767..3294237 + 471 WP_002431406.1 YlaC family protein -
HVV54_RS15990 3294376..3295926 + 1551 WP_181202748.1 EAL domain-containing protein -
HVV54_RS15995 3295968..3296321 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HVV54_RS16005 3296700..3297011 + 312 WP_000409907.1 MGMT family protein -
HVV54_RS16010 3297042..3297614 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T165804 WP_001280991.1 NZ_CP058057:3293054-3293272 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T165804 NZ_CP073974:3139196-3139303 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT165804 WP_000344803.1 NZ_CP058057:3292653-3293027 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT165804 NZ_CP073974:c3139148-3139082 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References