Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1303742..1304367 Replicon chromosome
Accession NZ_CP058057
Organism Escherichia fergusonii strain RHB02-C22

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag HVV54_RS06285 Protein ID WP_000911329.1
Coordinates 1303969..1304367 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag HVV54_RS06280 Protein ID WP_000450524.1
Coordinates 1303742..1303969 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV54_RS06255 1299544..1300014 - 471 WP_001068688.1 thioredoxin-dependent thiol peroxidase -
HVV54_RS06260 1300014..1300586 - 573 WP_000189057.1 glycine cleavage system transcriptional repressor -
HVV54_RS06265 1300733..1301611 + 879 WP_000494011.1 4-hydroxy-tetrahydrodipicolinate synthase -
HVV54_RS06270 1301628..1302662 + 1035 WP_002431657.1 outer membrane protein assembly factor BamC -
HVV54_RS06275 1302874..1303587 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
HVV54_RS06280 1303742..1303969 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
HVV54_RS06285 1303969..1304367 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
HVV54_RS06290 1304514..1305377 + 864 WP_001267498.1 neutral zinc metallopeptidase -
HVV54_RS06295 1305392..1307407 + 2016 WP_181203253.1 tRNA cytosine(34) acetyltransferase TmcA -
HVV54_RS06300 1307481..1308182 + 702 WP_105288162.1 esterase -
HVV54_RS06305 1308277..1308477 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T165793 WP_000911329.1 NZ_CP058057:1303969-1304367 [Escherichia fergusonii]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T165793 NZ_CP073974:109586-109837 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT165793 WP_000450524.1 NZ_CP058057:1303742-1303969 [Escherichia fergusonii]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT165793 NZ_CP073974:109834-110088 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References