Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 393225..393747 Replicon chromosome
Accession NZ_CP058057
Organism Escherichia fergusonii strain RHB02-C22

Toxin (Protein)


Gene name relE Uniprot ID A0A7W3EN85
Locus tag HVV54_RS01880 Protein ID WP_046083069.1
Coordinates 393457..393747 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7LMQ7
Locus tag HVV54_RS01875 Protein ID WP_000212726.1
Coordinates 393225..393467 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVV54_RS01855 389074..390447 + 1374 WP_001219809.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
HVV54_RS01860 390598..391149 - 552 WP_000166277.1 ribosome-associated protein -
HVV54_RS01865 391243..392595 + 1353 WP_001162171.1 metalloprotease PmbA -
HVV54_RS01870 392648..393034 + 387 WP_001232246.1 cytochrome b562 -
HVV54_RS01875 393225..393467 + 243 WP_000212726.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HVV54_RS01880 393457..393747 + 291 WP_046083069.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVV54_RS01885 393748..394212 - 465 WP_001106232.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HVV54_RS01890 394370..396508 - 2139 WP_000187805.1 anaerobic ribonucleoside-triphosphate reductase -
HVV54_RS01895 396902..398557 - 1656 WP_181203089.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11323.22 Da        Isoelectric Point: 10.3007

>T165786 WP_046083069.1 NZ_CP058057:393457-393747 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVTVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRRVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T165786 NZ_CP073962:c4156702-4156415 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9140.53 Da        Isoelectric Point: 5.1369

>AT165786 WP_000212726.1 NZ_CP058057:393225-393467 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRQLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT165786 NZ_CP073962:c4156428-4156126 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W3EN85

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3HXN7

References