Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3404161..3404815 Replicon chromosome
Accession NZ_CP057918
Organism Escherichia fergusonii strain RHB10-C04

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HVW38_RS16335 Protein ID WP_000244781.1
Coordinates 3404161..3404568 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HVW38_RS16340 Protein ID WP_000354046.1
Coordinates 3404549..3404815 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVW38_RS16315 3400118..3401851 - 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -
HVW38_RS16320 3401857..3402567 - 711 WP_046076902.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HVW38_RS16325 3402592..3403488 - 897 WP_046076901.1 site-specific tyrosine recombinase XerD -
HVW38_RS16330 3403600..3404121 + 522 WP_001055874.1 flavodoxin FldB -
HVW38_RS16335 3404161..3404568 - 408 WP_000244781.1 protein YgfX Toxin
HVW38_RS16340 3404549..3404815 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HVW38_RS16345 3405067..3406047 + 981 WP_046076900.1 tRNA-modifying protein YgfZ -
HVW38_RS16350 3406124..3406783 - 660 WP_000250283.1 hemolysin III family protein -
HVW38_RS16355 3406947..3407258 - 312 WP_001182952.1 N(4)-acetylcytidine aminohydrolase -
HVW38_RS16360 3407303..3408736 + 1434 WP_181575963.1 6-phospho-beta-glucosidase BglA -
HVW38_RS16365 3408784..3409677 - 894 WP_181576133.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T165776 WP_000244781.1 NZ_CP057918:c3404568-3404161 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T165776 NZ_CP073962:2067739-2067842 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT165776 WP_000354046.1 NZ_CP057918:c3404815-3404549 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT165776 NZ_CP073962:c2067880-2067609 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References